Press Release



Poxel Announces Results of its Combined General
Meeting Held on December 11, 2025


LYON, France, December 11, 2025 – POXEL SA (Euronext: POXEL - FR0012432516),
a clinical stage biopharmaceutical company developing innovative treatments for
chronic serious diseases with metabolic pathophysiology, including metabolic
dysfunction-associated steatohepatitis (MASH) and rare metabolic disorders,
today announces that it held its Combined General Meeting on Thursday,
December 11, 2025, at 10:00 am CET at the Mercure Lyon Centre Château Perrache
Hotel, located at 12 Cours de Verdun-Rambaud Esplanade de la Gare, 69002 Lyon,
France.

The number of voting rights held by shareholders present or represented was
19,381,917, representing a quorum of 36.123%.

Details on the voting results on all resolutions, the replay of the Combined General
Meeting as well as the presentation that was made during the meeting, are
available today on the Company’s website, in the Investors / Shareholder Info /
Annual General Meeting Documents section.

Poxel's Board of Directors welcomes the adoption of the resolutions and thanks
the company's shareholders for their confidence.

The next key step will be the validation of the recovery plan by the Lyon Economic
Court, scheduled for January 2026. This will enable the plan to be implemented at
the end of the ongoing collective proceedings, paving the way for a new future for
Poxel.


About Poxel SA

Poxel is a clinical stage biopharmaceutical company developing innovative
treatments for chronic serious diseases with metabolic pathophysiology,
including metabolic dysfunction-associated steatohepatitis (MASH) and rare
disorders. For the treatment of MASH, PXL065 (deuterium-stabilized
Rpioglitazone) met its primary endpoint in a streamlined Phase 2 trial (DESTINY-1).
In rare diseases, development of PXL770, a first-in-class direct adenosine
monophosphate-activated protein kinase (AMPK) activator, is focused on the
treatment of adrenoleukodystrophy (ALD) and autosomal dominant polycystic
kidney disease (ADPKD). TWYMEEG® (Imeglimin), Poxel’s first-in-class product that



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targets mitochondrial dysfunction, is now marketed for the treatment of type 2
diabetes in Japan by Sumitomo Pharma and Poxel expects to receive royalties and
5 sales-based payments. Poxel has a strategic partnership with Sumitomo Pharma
for Imeglimin in Japan. Listed on Euronext Paris, Poxel is headquartered in Lyon,
France, and has subsidiaries in Boston, MA, and Tokyo, Japan.

For more information, please visit: www.poxelpharma.com

Contacts - Investor relations / Media

NewCap
Théo Martin
investors@poxelpharma.com
+33 1 44 71 94 94




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